![]() In adults, NICE recommends methylphenidate and lisdexamfetamine as first-line treatments, but other European guidelines recommend psychostimulants as first-line options with no distinctions.Īndrea Cipriani, study lead and associate lecturer in the department of psychiatry at the University of Oxford, UK, said medication could be an important tool for ADHD and the evidence showed these were safe and effective treatments in the short term. The National Institute for Health and Care Excellence (NICE) already recommends methylphenidate as first-line drug treatment for children aged five years and over and young people with ADHD, with lisdexamfetamine and atomoxetine or guanfacine recommended as second and third options. In a large meta-analysis and systematic review, researchers looked at evidence from 133 double-blind randomised controlled trials - including 81 trials in children - for lisdexamfetamine, atomoxetine, bupropion, clonidine, guanfacine, methylphenidate and modafinil, compared with placebo over 12 weeks of treatment.įor the short-term treatment of ADHD, all of the drugs, except modafinil in adults, were more effective than placebo but were less effective and less tolerable in adults than children and adolescents, although it was unclear why.Ĭurrent guidelines on use of the drugs are inconsistent, the researchers pointed out. ![]() However, more evidence is needed on long-term effects of the drugs, and environmental modifications and other non-pharmacological treatments should be tried first, the researchers concluded in The Lancet Psychiatry on 7 August 2018. The research, which looked at evidence on the safety and efficacy of seven drugs used to treat the condition, also recommended that amphetamines should be the first choice in adults who have ADHD. The preferred first-line treatment for attention-deficit hyperactivity disorder (ADHD) in children is methylphenidate, a review of the evidence has concluded Journal of Pharmaceutical Health Services Research. ![]()
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